More time with less lines.

Daxxify wrinkle relaxer

DAXXIFY Frown Line Treatment

DAXXIFY (DaxibotulinumA) or “Daxi” is the newest FDA-approved neuromodulator to hit the market. Like other tried-and-true products, “Daxi” uses botulinum type A to treat and prevent wrinkles more specifically, severe frown lines. The biggest difference between DAXXIFY compared to other neurotoxins is its unique peptide formulation and duration. While most neurotoxins currently on the market an average three-to-four-month duration of efficacy, DAXXIFY claims to average six months, or possibly longer.


DAXXIFY works fast and lasts longer than other frown line treatments. You may see results as soon as the next day after treatment, and typically within 2 days.

50% of patients in clinical studies had no or minor frown lines 6 months after treatments.


94% of patients preferred DAXXIFY® over their previous frown line treatment.

Got Questions?


DAXXIFY is FDA approved to smooth moderate to severe lines between the brows. It is the only frown line treatment powered by a peptide. The active ingredient in DAXXIFY is a purified protein called botulinum toxin type A.

DAXXIFY is the only frown line treatment powered by a peptide. It’s fast acting, long lasting and slow to wear off.

All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, Botox® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses HSA as a stabilizer and cow’s milk protein as a protectant.

DAXXIFY is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.

In short, no, and here’s why. Units are like fingerprints—they are a proprietary measurement of a treatment’s unique potency.

Because of the differences in how treatments are formulated and tested, you cannot compare or convert Units between them, just like you cannot compare 2 fingerprints.

A clearer way to understand dosing is to look at how many nanograms of active ingredient (botulinum toxin type A) a product has.

Double the Units does not mean double the dose.

DAXXIFY is safe. It was studied in the largest-ever clinical study for a frown line treatment and included more than 2,800 people across different ages and skin types. Here are some things you should know about DAXXIFY®:

  • There were no serious treatment-related side effects
  • The active ingredient in DAXXIFY is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years
  • 96% of people treated with DAXXIFY were satisfied with their results

The safety and efficacy of DAXXIFY is well established, with more than 20 years of research. In fact, DAXXIFY has been studied in the largest-ever phase 3 clinical trial conducted for a frown line treatment and included more than 2,800 people across different ages and with different skin types. DAXXIFY® was studied in patients with varying skin types.

DAXXIFY is well-studied, with no serious treatment-related side effects seen in large-scale clinical trials.

The most common side effects observed in clinical trials occurred within one to two weeks after injection and lasted only a short while. This is consistent with other frown line treatments.

Ask your aesthetic provider for pre-treatment instructions prior to your appointment.

A list of common avoidances before treatment include, but are not limited to:

  • Retin-A
  • Blood thinners
  • Muscle relaxants
  • Fish or oils rich in omega 3
  • Allergy medication
  • Topical steroids
  • Sleep medications and supplements
  • Aspirin
  • St. John’s Wort
  • Supplements containing Vitamin E
  • Ibuprofen

If you’re like most people, you probably get a frown line treatment around twice a year. But here’s the thing: conventional treatments only last 3–4 months. If you are not able to get treated every 3-4 months, that means you may spend the next 2-3 months of the year with those frown lines staring back at you between treatments. That’s up to 4-6 months of total wear off time per year!

In clinical trials, at least 50% of patients showed results in frown lines at 6 months.

With DAXXIFY you may see results early as the day after treatment, and typically within two days.

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